EFFICACY OF PLATELET-RICH PLASMA INJECTION VERSUS OXYGEN-OZONE THERAPY FOR THE TREATMENT OF KNEE OSTEOARTHRITIS : A META-ANALYSIS AND SYSTEMATIC REVIEW
Krida Wacana Christian University
Departemen Orthopaedi dan Traumatologi, RS Permata Bekasi, Bekasi, Indonesia
Departemen Orthopaedi dan Traumatologi, RSAU Esnawan Antariksa, Jakarta Timur, Indonesia
Fakultas Kedokteran Universitas Pelita Harapan, Karawaci, Indonesia
Introduction. Knee osteoarthritis (KOA), a degenerative knee condition, represents a major Indonesian public health issue because it consistently damages patients’ quality of life. Recent studies have explored the intra-articular injection of platelet-rich plasma and oxygen-ozone therapy as potential treatments for knee osteoarthritis. This review aimed to evaluate the effect of platelet-rich plasma (PRP) injection compared to oxygen-ozone therapy for treating knee osteoarthritis patients. Method. The reporting methodology of this work followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. A literature search was conducted through PubMed and Google Scholar by combining several keywords, including PRP Injection with oxygen-ozone therapy for patients affected by KOA. The Cochrane Risk of Bias 2 (ROB 2) tool was employed to assess the risk of bias. Result&Analysis. The meta-analysis included 251 participants from these 4 Randomized Controlled Trials (RCTs) the results indicated no statistically significant difference between PRP injection and oxygen-ozone therapy in terms of the visual analog scale score and the mean difference in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale at the 1-month follow-up. However, a significant difference was observed between the two interventions in the WOMAC subscales for stiffness and physical function. Discussion. This meta-analysis shows that KOA patients might achieve better pain relief together with improved function outcomes from PRP injections than from oxygen-ozone therapy based on joint stiffness and functionality WOMAC scores.
Keywords: Platelet Rich Plasma Oxygen ozone Therapy knee osteoarthritis WOMAC Score osteoarthritis
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